Pros
There are some fantastic people and opportunities possible
Cons
The pros depend on who you work for. There are many people at Roche in the UK that are deadwood, sitting in senior positions without adding anything to the business. If you work for one of these people then you are generally fine if you can create benefit to them (ie make them look good; allow them to take all the glory) up to a point. However, if you have ambition and want to progress you will find there is little opportunity because of this deadwood. Even if you excel you will rarely find an opportunity because people like to keep you below your capabilities (this has a corresponding effect on pay, whereby Roche is in the bottom quartile of salaries). This has lead to a culture of bullying in the UK, literally dozens and dozens of people have been forced out as they are cheaper to get out the door then the 'lifers' that are bullying. The problem tends to be made worse by a HR department that panda's to the people creating the problem, because they lack the skills and experience to do otherwise.