Pros
HLR has the infra-structure to do good research and innovating product development. There is resources available to do good science. There is access to advanced scientific knowledge to do good basic and applied research.
Cons
Croniism: employees either do what they're told or lose their jobs if they're ever considered "challenging" management competency/decision making. There is systematic witholding critical information for scientist to do research (insecurity from the top down). There is systematic covering up of mistakes from the bottom up, especially lower lever managements (dishonesty). There is absolutely no respect and no support for the foot soldier employees, thus talents are wasted. Meanwhile there are so many lazy employees taking advantage of the cronies in the incompetence management and just benefit in the "Roche welfare" system (one director to another: you hire my wife, I hire your wife).